Western Health’s geographical boundaries are from Port aux Basques southeast to Francois, northwest to Bartlett’s Harbour, and on the eastern boundary north to Jackson’s Arm. Within this geographical region, Western Health serves a population of approximately 77,980 residents.

Western Health provides a broad range of programs and services to the people of Western Newfoundland. These programs and services are based in community and facility settings. Western Health provides community based services from 24 office sites, community based medical services from 26 medical clinic sites (including traveling clinic sites), and eight health facilities. The health facilities include two hospitals: Sir Thomas Roddick Hospital in Stephenville and Western Memorial Regional Hospital in Corner Brook; four health centres: Dr. Charles L. LeGrow Health Centre in Port aux Basques, Bonne Bay Health Centre in Norris Point, Calder Health Centre in Burgeo and Rufus Guinchard Health Centre in Port Saunders; and two long term care centres: Corner Brook Long Term Care Centre in Corner Brook and Bay St. George Long Term Care Centre in Stephenville Crossing. Within its facilities, Western Health operates 293 acute care beds, and 434 long term care beds, 40 enhanced assisted living beds for individuals with mild to moderate dementia, as well as 14 restorative care beds.

Western Health accomplishes their mandate through six lines of business: promoting health and well-being; preventing illness and injury; providing supportive care; treating illness and injury; providing rehabilitative services; administering distinctive provincial programs. Programs and services that promote health and well-being include health promotion and health protection activities. Preventing illness and injury occurs through early intervention and use of the best possible information as with screening and injury prevention activities. Programs and services that provide supportive care include: community health nursing; community supportive services; maternal, child and family health; long term care and residential services; mental health and addictions. Programs and services that treat illness and injury are primary and secondary in nature and include ambulatory care, emergency, maternal, medical, pediatric and surgical services. Rehabilitation services such as physiotherapy, occupational therapy and speech-language are provided in community and facility settings. Western Health is also responsible for Humberwood Treatment Centre, a provincial inpatient addictions facility. In addition, Western Health operates the Western Regional School of Nursing.

Western Health's regional office is located in Corner Brook. The organization employs over 3,100 staff who work in approximately 50 separate buildings throughout the region. Approximately 84 per cent of staff is female.

Western Health has approximately 1,600 volunteers who assist in delivering a number of programs and services and special events within acute care, long term care and community, which enhance the quality of life for patients, residents, and clients.

In 2017-2018, Western Health has an operating budget of $373 million with most of its revenue coming from provincial plan funding through the Department of Health and Community Services. Other notable revenues include the foundations and auxiliaries, long term care and the Medical Care Plan (MCP).

Major expenditures include: salaries, direct client payments, capital costs, debt financing, diagnostic and therapeutic services, pharmaceuticals and medical supplies.